ARDMS AE-Adult-Echocardiography AE Adult Echocardiography Examination Exam Practice Test

A continuous murmur, heard throughout systole and diastole, is most characteristically caused by a patent ductus arteriosus (PDA). PDA represents persistent communication between the aorta and pulmonary artery, allowing continuous blood flow during both phases of the cardiac cycle.

Ventricular septal defect usually produces a holosystolic murmur. Concomitant aortic stenosis and mitral regurgitation cause separate murmurs but not continuous. Ebstein anomaly with atrial septal defect typically produces murmurs related to tricuspid regurgitation or ASD but not a continuous murmur.

This clinical correlation is detailed in the "Textbook of Clinical Echocardiography, 6e", Chapter on Congenital Heart Disease and Murmur Etiologies【20:420-425†Textbook of Clinical Echocardiography】.

The echocardiographic video shows hypokinesis or akinesis of the inferolateral wall of the left ventricle. This myocardial territory is predominantly supplied by the left circumflex coronary artery.

The right coronary artery primarily supplies the inferior wall and right ventricle. The left anterior descending artery supplies the anterior and septal walls. The posterior descending artery supplies the inferior wall, usually supplied by the right coronary artery or sometimes the circumflex.

These segmental coronary territories are described in ASE stress echocardiography and regional wall motion assessment guidelines【12:ASE Stress Echocardiography Guidelines†p.300-310】【16:Textbook of Clinical Echocardiography, 6e†p.380-385】.

In severe tricuspid regurgitation (TR), the regurgitant jet flows back from the right ventricle into the right atrium during systole, causing reversal of flow in the hepatic veins during the same phase. On Doppler echocardiography, this manifests as systolic flow reversal in the hepatic veins, which is a hallmark sign of severe TR.

Normally, hepatic vein flow consists of a predominant systolic forward flow into the right atrium. However, in severe TR, the high pressure in the right atrium during systole causes retrograde flow in the hepatic veins. This pattern is diagnostic and aids in severity assessment.

Diastolic flow reversal is uncommon in TR and more associated with other pathologies. Atrial flow reversal in systole or biphasic flow reversal in diastole are not recognized patterns for severe TR.

This is described in detail in the "Textbook of Clinical Echocardiography, 6e", Chapter on Right Heart and Tricuspid Valve Disease, with Doppler patterns illustrated for hepatic vein flow in tricuspid regurgitation【20:330-335†Textbook of Clinical Echocardiography】.

Pulmonary artery end-diastolic pressure (PAEDP) can be estimated noninvasively by measuring the end-diastolic velocity of pulmonary regurgitation (pulmonary insufficiency) using continuous-wave Doppler. The pressure gradient between the pulmonary artery and right ventricle at end-diastole is calculated using the modified Bernoulli equation from this velocity.

Tricuspid insufficiency is used to estimate right ventricular systolic pressure. Tricuspid inflow and pulmonary inflow velocities provide information on diastolic function but not direct pressure gradients.

This method is well validated and included in ASE guidelines for pulmonary hypertension assessment and Doppler hemodynamics【16:Textbook of Clinical Echocardiography, 6e†p.300-305】【12:ASE Doppler Guidelines†p.110-115】.

Comprehensive and Detailed Explanation From Exact Extract:

Atrioventricular canal defect (AV canal defect) is a congenital cardiac malformation characterized by defects in the atrial and ventricular septa, along with abnormalities of the atrioventricular valves including cleft mitral valve. These features collectively cause shunting and valve regurgitation.

Ebstein anomaly primarily involves the tricuspid valve and right atrium, Marfan syndrome is a connective tissue disorder with different manifestations, and Shone syndrome involves left-sided obstructive lesions.

This is clearly outlined in the "Textbook of Clinical Echocardiography, 6e", Chapter on Congenital Heart Defects - Atrioventricular Septal Defects【20:120-125†Textbook of Clinical Echocardiography】.

The structure indicated by the arrow in the right ventricle is the moderator band. The moderator band is a muscular band of tissue that crosses the right ventricular cavity from the interventricular septum to the anterior papillary muscle. It contains part of the right bundle branch of the conduction system and is a normal anatomical structure identifiable on echocardiography.

False tendons are fibrous or muscular strands within the left ventricle, not the right. The Chiari network is a mobile, net-like structure in the right atrium near the inferior vena cava and atrial septum. The Eustachian valve is a crescent-shaped ridge at the entrance of the inferior vena cava into the right atrium.

The moderator band is important to recognize to avoid misinterpretation as a pathological mass or thrombus.

This is detailed in the "Textbook of Clinical Echocardiography, 6e", Chapter on Right Ventricular Anatomy and Echocardiographic Landmarks【20:150-155†Textbook of Clinical Echocardiography】.

Peak tricuspid regurgitant velocity (TRV) allows estimation of right ventricular systolic pressure (RVSP) using the simplified Bernoulli equation: RVSP = 4 × (TRV)^2 + estimated right atrial pressure.

This measurement is important for assessing pulmonary hypertension indirectly.

Right atrial pressure is estimated separately, pulmonary artery diastolic pressure and mean pressure require additional measurements.

This application is discussed in the "Textbook of Clinical Echocardiography, 6e", Chapter on Right Heart Pressure Estimation【20:335-340†Textbook of Clinical Echocardiography】.

The strain imaging shown is a classic example of the "apical sparing" pattern, highly characteristic of cardiac amyloidosis. In cardiac amyloidosis, the basal and mid segments of the left ventricle show markedly reduced longitudinal strain (represented here by more positive or less negative strain values), while the apical segments retain relatively preserved strain (more negative strain values). This "cherry on top" or "bull's eye" pattern with apical strain preserved distinguishes amyloidosis from other causes of LV dysfunction.

This pattern is not typical of apical hypertrophy, which would show focal thickening and abnormal strain limited to the apex. Non-ischemic cardiomyopathy generally has a more diffuse and uniform reduction in strain without the apical sparing. Right coronary artery infarcts affect the inferior and posterior walls and would have segmental strain abnormalities corresponding to the infarct distribution, not the typical apical sparing.

The left ventricular global longitudinal strain (GLS) in amyloidosis is typically severely reduced, but the relative preservation of apical strain is a hallmark useful for diagnosis, as described in the "Textbook of Clinical Echocardiography, 6e" (Chapter on strain imaging and infiltrative cardiomyopathies) .

Mitral valve prolapse (MVP) occurs during ventricular contraction (systole). Specifically, during systole, the increased pressure in the left ventricle causes the mitral valve leaflets to billow or prolapse back into the left atrium. This abnormal systolic displacement of the mitral leaflets beyond the annular plane leads to mitral regurgitation in many cases.

The echocardiographic hallmark of MVP is systolic bowing or displacement of the mitral leaflets into the left atrium, best visualized in parasternal long-axis or apical views during ventricular contraction. MVP is not seen during ventricular filling phases such as early filling, atrial systole, or diastasis because the leaflets are normally open or positioned differently.

This is well-documented in the "Textbook of Clinical Echocardiography, 6e", Chapter on Mitral Valve Disease, explaining the pathophysiology of MVP and its timing during the cardiac cycle【20:390-395†Textbook of Clinical Echocardiography】.

Comprehensive and Detailed Explanation From Exact Extract:

The superior vena cava (SVC) is best visualized in its long axis from the suprasternal notch window. This approach provides a longitudinal view of the great vessels including the aortic arch and the SVC entering the right atrium. Other standard transthoracic echocardiographic views such as the parasternal long axis or apical views do not provide clear visualization of the SVC in its long axis. The subcostal four-chamber view typically shows the inferior vena cava but not the superior vena cava.

The suprasternal notch window is particularly useful for evaluating flow and anatomy in the SVC and the ascending aorta. This view allows clear identification of the vessel course as it enters the right atrium, making it valuable in assessment of venous return and possible pathologies involving the SVC.

This is supported in the echocardiography text under the description of transthoracic views for major venous structures and great vessels, which identifies the suprasternal notch as the best window for the long-axis visualization of the superior vena cava.

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The recommended method to measure left atrial diameter in the parasternal long axis view is the inner edge to inner edge technique, perpendicular to the aortic root, measured at end-diastole. This approach provides the most reproducible and standardized measurement.

Measurement parallel to the aortic root or at end-systole is less accurate. Outer edge measurements overestimate size.

ASE chamber quantification guidelines specify this method for standardization and reproducibility in adult echocardiography practice【12:ASE Chamber Quantification Guidelines†p.90-95】【16:Textbook of Clinical Echocardiography, 6e†p.120-125】.

The Valsalva maneuver transiently reduces preload, which can unmask or exaggerate diastolic dysfunction during mitral inflow Doppler assessment. During Valsalva, changes in mitral E and A wave velocities can differentiate between normal and pseudonormal filling patterns by observing alterations in filling pressures.

Hand grip, leg air cycling, and squatting affect afterload and preload differently but are less specific for assessing diastolic dysfunction via mitral Doppler.

This technique is outlined in the "Textbook of Clinical Echocardiography, 6e", Chapter on Diastolic Function Assessment and Maneuvers【20:210-215†Textbook of Clinical Echocardiography】.

Tricuspid annular plane systolic excursion (TAPSE) is measured as the linear displacement of the tricuspid annulus during systole and is expressed in centimeters (cm). It quantifies right ventricular longitudinal systolic function.

Centimeters per second is a velocity measurement used in tissue Doppler imaging. Milliliters per minute refers to volume flow, and millimeters of mercury measures pressure.

This is standardized in the "Textbook of Clinical Echocardiography, 6e", Chapter on Right Ventricular Functional Assessment【20:320-325†Textbook of Clinical Echocardiography】.

Atrial myxomas are the most common primary cardiac tumors in adults and are typically attached to the interatrial septum at the fossa ovalis region of the left atrium. These tumors often arise from a stalk and are mobile masses that may cause obstruction of the mitral valve or embolic events.

The echocardiographic hallmark of atrial myxoma is a well-circumscribed, pedunculated mass attached near the fossa ovalis. Transesophageal echocardiography (TEE) is especially useful in visualizing the attachment site and mobility of the myxoma.

Other cardiac masses have different typical locations: papillary fibroelastomas usually arise from valvular surfaces (often aortic or mitral valves), sarcomas are rare malignant tumors that can invade multiple areas, and lipomas usually involve the atrial septum but spare the fossa ovalis and have a characteristic echogenic appearance.

The "Textbook of Clinical Echocardiography" describes atrial myxomas as mobile masses attached to the fossa ovalis in the left atrium and emphasizes their characteristic appearance on TEE imaging, which is critical for diagnosis and surgical planning.

Comprehensive and Detailed Explanation From Exact Extract:

The left ventricular dP/dt is a measure of the rate of rise in left ventricular pressure during isovolumic contraction, which reflects systolic function. It is derived from Doppler echocardiography by measuring the time interval between mitral regurgitant jet velocities of 1 m/s and 3 m/s. Using the simplified Bernoulli equation, the pressure gradient at each velocity is calculated, and the rate of pressure rise (dP/dt) is calculated by dividing the pressure difference by the time interval between these velocities.

A normal left ventricular dP/dt is generally considered to be greater than 1200 mmHg/s. Values lower than this indicate impaired systolic function, as the ventricle is slower to generate pressure during contraction.

For example, a measured time interval of 36 milliseconds (0.036 seconds) between the MR velocities of 1 and 3 m/s corresponds to a dP/dt of approximately 889 mmHg/s, which is mildly reduced, indicating some systolic dysfunction.

The exact extract from the "Textbook of Clinical Echocardiography, 6e" states that normal dP/dt values are typically above 1000 mmHg/s, with >1200 mmHg/s considered a robust indicator of normal systolic function. This measure is useful but requires a measurable mitral regurgitation jet and consistent alignment of the ultrasound beam. Variability in measurement can occur based on technical factors, but the dP/dt remains a useful parameter to quantify systolic function noninvasively.

The echocardiographic image shows measurement of the ascending aorta, identified by its position above the aortic valve and before the arch vessels. The ascending aorta is a critical region assessed for dilation or aneurysm.

The sinus of Valsalva refers to the dilated portion just above the aortic valve cusps, while the aortic root includes the annulus, sinuses, and sinotubular junction. The descending aorta is posterior and visualized in other windows.

This measurement and its importance are detailed in the "Textbook of Clinical Echocardiography, 6e", Chapter on Aortic Root and Ascending Aorta Evaluation【20:380-385†Textbook of Clinical Echocardiography】.

Comprehensive and Detailed Explanation From Exact Extract:

Pulmonary capillary wedge pressure (PCWP) is obtained by advancing a balloon-tipped catheter into a small branch of the pulmonary artery and inflating the balloon to "wedge" the catheter, thereby occluding forward blood flow and measuring the pressure distal to the occlusion. The measured pressure reflects the pressure in the pulmonary venous system, which closely approximates left atrial pressure (LAP) under normal conditions.

Since the left atrium receives pulmonary venous return before the blood enters the left ventricle, PCWP is a surrogate for LAP, which in turn reflects left ventricular end-diastolic pressure (LVEDP) in the absence of mitral valve disease or pulmonary venous obstruction. PCWP is widely used in clinical and echocardiographic contexts to estimate left heart filling pressures.

It does not estimate right atrial, right ventricular, or left ventricular pressures directly. Right atrial pressure is measured via central venous pressure, right ventricular pressure by catheterization, and left ventricular pressure by direct catheterization.

This concept is extensively discussed in the "Textbook of Clinical Echocardiography, 6e", Chapter on Hemodynamics and Doppler Assessment, with specific emphasis on the use of PCWP to estimate left atrial pressure【20:200-210†Textbook of Clinical Echocardiography】.

Comprehensive and Detailed Explanation From Exact Extract:

Contrast echocardiography is recommended to enhance the visualization of left ventricular endocardial borders when the image quality is suboptimal. Specifically, contrast agents should be used when at least three contiguous left ventricular segments are poorly visualized on standard two-dimensional imaging. This approach improves the accuracy and reliability of assessing regional wall motion and global systolic function.

The use of contrast is particularly important during stress echocardiography to ensure detection of ischemic segments, which might otherwise be missed due to inadequate image quality. Studies suggest that contrast enhancement is required in approximately 30% to 50% of stress echocardiographic studies depending on patient factors and laboratory practices.

These recommendations are detailed in the echocardiography guidelines and in the "Textbook of Clinical Echocardiography, 6e" (Chapter 8: Coronary Artery Disease and Stress Echocardiography) which emphasize the utility of contrast agents for better endocardial border definition when at least three segments are not clearly seen .

The echocardiographic video shows a defect in the ventricular septum with left-to-right shunting consistent with an ischemic ventricular septal defect (VSD), a mechanical complication of myocardial infarction. The defect allows blood flow between the left and right ventricles.

Coronary artery aneurysm appears as dilated coronary vessels, not a septal defect. Tricuspid regurgitation involves the right atrioventricular valve and is identified differently. Pseudoaneurysm of the apex is a contained myocardial rupture with narrow neck and does not involve septal communication.

This complication and its echocardiographic features are described in the "Textbook of Clinical Echocardiography, 6e", Chapter on Post-Infarction Mechanical Complications【20:430-435†Textbook of Clinical Echocardiography】.

The echocardiographic image/video shows decreased brightness and penetration in the near field, making the anterior cardiac structures poorly visualized while deeper structures appear brighter. This indicates under-gain in the near field.

Increasing the time gain compensation (TGC) in the near field enhances the signal strength of superficial structures without affecting deeper tissues. This adjustment improves image quality by balancing the brightness across the field.

Increasing compression or decreasing overall gain would reduce the signal globally and are not specific for near field optimization. Decreasing TGC in the far field would reduce brightness deeper but does not address near-field issues.

This principle is outlined in the "Textbook of Clinical Echocardiography, 6e", Chapter on Image Optimization and Technical Settings【20:70-75†Textbook of Clinical Echocardiography】.

Comprehensive and Detailed Explanation From Exact Extract:

The left ventricular end-diastolic diameter (LVEDD) is measured at end-diastole, which is conventionally defined as the onset of the QRS complex on the electrocardiogram (ECG). This corresponds to the end of ventricular filling and just before ventricular contraction begins.

Measuring LVEDD at this point ensures consistency and accuracy for assessment of ventricular size and function. Measurement at the onset of the P wave would be too early (atrial contraction). The first frame after aortic valve closure corresponds to end-systole, and after mitral valve closure is during systole.

This timing is standard as per guidelines outlined in the "Textbook of Clinical Echocardiography, 6e", Chapter on Cardiac Chamber Quantification【20:60-65†Textbook of Clinical Echocardiography】.

In significant aortic valve regurgitation (AR), the continuous wave Doppler signal across the valve demonstrates a rapid decline in regurgitant jet velocity, resulting in a pressure half-time (PHT) less than 250 milliseconds. A short PHT indicates severe AR with rapid equalization of aortic and left ventricular pressures during diastole.

Pulsed wave Doppler forward flow in the abdominal aorta evaluates stroke volume but does not directly indicate AR severity. Vena contracta to LVOT diameter ratio less than 25% would indicate mild AR, not significant. Peak velocity ≥4.5 m/s is more characteristic of aortic stenosis rather than regurgitation.

This criterion for AR severity using CW Doppler PHT is described in the "Textbook of Clinical Echocardiography, 6e", Chapter on Aortic Regurgitation Doppler Assessment【20:375-380†Textbook of Clinical Echocardiography】.

Comprehensive and Detailed Explanation From Exact Extract:

The P wave on the ECG corresponds to atrial depolarization, which precedes atrial contraction (atrial systole). On echocardiography, atrial contraction can be observed as the atrial "kick," contributing to ventricular filling during late diastole.

Ventricular contraction (QRS complex) and ventricular relaxation (T wave) correspond to other phases of the cardiac cycle. Atrial relaxation occurs during ventricular systole but is not represented by the P wave.

This timing relationship is critical for correlating echocardiographic Doppler inflow patterns, such as the late diastolic A wave, with the ECG. These concepts are outlined in the foundational echocardiography references, including ASE guidelines and the "Textbook of Clinical Echocardiography"【16:Textbook of Clinical Echocardiography, 6e†p.150-155】【12:ASE Echocardiography Guidelines†p.50-55】.

Osler nodes are tender, erythematous nodules typically located on the fingers and toes, and are a classic sign of infective endocarditis (IE). They represent immune complex deposition and microemboli causing localized vasculitis.

Carcinoid heart disease presents with right-sided valve fibrosis and not with Osler nodes. Lambl excrescences are small filiform valvular strands without clinical manifestations such as Osler nodes. Papillary fibroelastomas are benign cardiac tumors that may cause emboli but not immune-mediated skin lesions.

This classic clinical sign and its echocardiographic correlation in IE are discussed in the "Textbook of Clinical Echocardiography, 6e", Chapter on Infective Endocarditis【20:400-405†Textbook of Clinical Echocardiography】.

The image shows incomplete leaflet apposition of the tricuspid valve leaflets with a visible gap, indicating malcoaptation. This is a common cause of tricuspid regurgitation due to leaflet tethering or annular dilation.

Normal coaptation would show complete leaflet closure. Stenosis would show restricted leaflet motion but not malcoaptation. Endocarditis involves vegetations and leaflet destruction, which are not evident here.

This echocardiographic feature is described in the "Textbook of Clinical Echocardiography, 6e", Chapter on Tricuspid Valve Disease【20:330-335†Textbook of Clinical Echocardiography】.

TAPSE measures the longitudinal systolic excursion of the tricuspid annulus towards the apex and is a widely used echocardiographic parameter of right ventricular systolic function. It is not a measure of diastolic function nor an indirect measure of left ventricular function.

TAPSE is relatively angle independent because it is measured in M-mode from the apical four-chamber view aligned with annular motion.

The lower normal limit for TAPSE is generally accepted as 16 mm, but 13 mm is sometimes cited as a threshold below which right ventricular systolic dysfunction is suggested.

This information is presented in the "Textbook of Clinical Echocardiography, 6e", Chapter on Right Ventricular Function Assessment【20:320-325†Textbook of Clinical Echocardiography

The mitral valve filling pattern characterized by a long deceleration time and a reduced E/A ratio (less than 1, such as 0.6) is consistent with impaired relaxation. This pattern is typically seen in early diastolic dysfunction, where there is slowed ventricular relaxation, resulting in reduced early diastolic filling (E wave) and a compensatory increase in atrial contraction contribution (A wave).

Impaired relaxation pattern shows:

E/A ratio < 1 (e.g., 0.6)

Prolonged deceleration time (>200 ms)

Prolonged isovolumic relaxation time (IVRT)

This pattern differs from restrictive filling, which has a high E/A ratio (>2), shortened deceleration time (<150 ms), and elevated left atrial pressures. Pseudonormal filling has a normal or near-normal E/A ratio but elevated filling pressures that mask underlying dysfunction and requires further evaluation with tissue Doppler or pulmonary venous flow for diagnosis. Normal filling has a typical E/A ratio around 1 to 1.5 with normal deceleration times.

The textbook details that impaired relaxation is the earliest sign of diastolic dysfunction and describes the prolongation of the deceleration time and reduced E/A ratio as hallmark findings of this stage.

The parasternal long axis (PLAX) view provides visualization of the left ventricle, left atrium, mitral and aortic valves, and importantly, the coronary sinus located posteriorly between the left atrium and left ventricle.

The pulmonic valve is best visualized in the parasternal short axis or suprasternal views. The eustachian valve is in the right atrium and visualized best in subcostal or apical views. The left atrial appendage is usually seen in transesophageal echocardiography.

This anatomical visualization is discussed in standard echocardiography textbooks and ASE imaging protocols【12:ASE Imaging Guidelines†p.70-75】【16:Textbook of Clinical Echocardiography, 6e†p.100-105】.

During the strain phase of the Valsalva maneuver, intrathoracic pressure increases significantly due to forced expiration against a closed glottis. This elevated intrathoracic pressure compresses the thoracic veins, leading to decreased venous return to the heart, which causes a reduction in preload (the volume of blood filling the ventricles during diastole). This reduction in preload is transient and results in decreased stroke volume and cardiac output.

This physiologic response is exploited during echocardiographic evaluation to unmask pseudonormal filling patterns of the left ventricle and to assess diastolic function. For example, during the strain phase, the early mitral inflow velocity (E wave) decreases due to reduced preload, and the E/A ratio can normalize or reverse if diastolic dysfunction is present.

The strain phase does not decrease afterload; in fact, afterload can transiently increase during other phases, but the hallmark of the strain phase is decreased preload.

This explanation is detailed in the "Textbook of Clinical Echocardiography, 6e," which explains the hemodynamic changes during the Valsalva maneuver and its clinical application in echocardiographic assessment of diastolic function .

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Constrictive pericarditis is characterized by thickening and fibrosis of the pericardium which restricts diastolic filling of the ventricles. Key echocardiographic features include a characteristic interventricular septal "bounce" or shift during early diastole due to the abrupt cessation of ventricular filling imposed by the rigid pericardium. This septal bounce reflects rapid early diastolic filling followed by a sudden halt as filling pressures equalize, a hallmark of constriction physiology.

Additionally, Doppler studies show marked respiratory variation in mitral and tricuspid inflow velocities (>25%), with an inspiratory increase in tricuspid inflow and a decrease in mitral inflow velocity, reflecting ventricular interdependence caused by the noncompliant pericardium. The mitral inflow typically shows a large E-wave with a small or absent A-wave and a steep deceleration slope, but importantly these velocities vary significantly with respiration, which is not the case in restrictive cardiomyopathy.

Hepatic vein Doppler often reveals a prominent a-wave and a deep y-descent with increased diastolic flow reversal during expiration, indicating elevated right atrial pressures and constrictive physiology.

The inferior vena cava (IVC) is usually dilated and shows no inspiratory collapse (i.e., no normal collapse with sniff test) because of elevated right atrial pressure and impaired venous return.

Therefore:

Option A is incorrect because mitral inflow in constrictive pericarditis shows significant respiratory variation, not absence of it.

Option B is incorrect because the hepatic vein is typically dilated with abnormal flow patterns, not normal size.

Option C is incorrect because the IVC is dilated and does NOT collapse normally with inspiration/sniff in constrictive pericarditis.

Option D is correct because the interventricular septal bounce is a classic feature reflecting ventricular interdependence and constrictive physiology.

These findings are summarized in the "Textbook of Clinical Echocardiography, 6e" (Catherine M. Otto, MD), Chapter 10 (Pericardial Disease), pages 280–285, with key illustrations showing septal bounce, Doppler inflow variations, hepatic vein flow patterns, and IVC findings in constrictive pericarditis. The "Mayo Clinic criteria" for echocardiographic diagnosis also emphasize ventricular septal shift as a critical feature, often combined with tissue Doppler annular velocity patterns and hepatic vein diastolic flow reversal for high diagnostic accuracy.

In interrupted aortic arch, the normal continuity between the ascending and descending aorta is disrupted. The patent ductus arteriosus (PDA) provides a vital conduit for blood to flow from the pulmonary artery to the descending aorta, maintaining systemic circulation distal to the interruption.

Persistent left superior vena cava and left carotid artery do not provide this flow. The foramen ovale is an atrial-level shunt and does not compensate for interrupted aortic arch.

This clinical anatomy is described in the "Textbook of Clinical Echocardiography, 6e", Chapter on Congenital Aortic Arch Anomalies【20:135-140†Textbook of Clinical Echocardiography】.

Ventricular depolarization begins with the electrical impulse traveling from the atrioventricular (AV) node to the Bundle of His, which then bifurcates into the right and left bundle branches. From the bundle branches, the impulse travels to the Purkinje fibers, which rapidly distribute the impulse to ventricular myocardium causing ventricular contraction.

Option A is incorrect because the impulse does not travel from the right to the left bundle branch; they run parallel. Option B describes atrial conduction. Option C is incorrect because the AV node precedes the Bundle of His, not the reverse.

This conduction pathway is detailed in the "Textbook of Clinical Echocardiography, 6e", Chapter on Cardiac Electrophysiology【20:40-45†Textbook of Clinical Echocardiography】.

The Doppler tissue imaging waveform shown indicates the systolic annular velocity of the tricuspid valve annulus, labeled as S’. This measurement reflects right ventricular systolic function by quantifying the velocity of longitudinal myocardial motion during systole.

The a’ wave corresponds to atrial contraction, not systole. S’ assesses systolic function, whereas e’ and a’ relate to diastolic phases.

This assessment method is detailed in the "Textbook of Clinical Echocardiography, 6e", Chapter on Right Ventricular Function and Tissue Doppler Imaging【20:320-325†Textbook of Clinical Echocardiography】.

Aortic stenosis (AS) is the valvular lesion most commonly requiring evaluation with a non-imaging (pedoff) continuous wave Doppler transducer. This specialized probe allows the operator to align the Doppler beam parallel to high-velocity aortic jets to accurately measure peak and mean gradients across the stenotic aortic valve.

While imaging Doppler can estimate gradients, non-imaging CW Doppler is essential for precise quantification, especially in difficult acoustic windows or when maximal velocities need to be captured.

Mitral and tricuspid regurgitations and pulmonic stenosis are typically assessed with imaging transducers, as jet orientation is more variable.

This is highlighted in the "Textbook of Clinical Echocardiography, 6e", Chapter on Doppler Hemodynamics and Valvular Stenosis Assessment【20:310-315†Textbook of Clinical Echocardiography】.

Acute severe aortic regurgitation causes rapid volume overload of the left ventricle during diastole, leading to a marked increase in left ventricular end-diastolic pressure (LVEDP). This elevated LVEDP results from the sudden return of blood into the ventricle and impaired compliance.

End-systolic pressure is not primarily affected. Early-diastolic pressure changes relate to aortic pressure but LVEDP is critical. Early-systolic pressure is not typically affected by AR.

This hemodynamic effect is discussed in the "Textbook of Clinical Echocardiography, 6e", Chapter on Aortic Regurgitation and Hemodynamics【20:375-380†Textbook of Clinical Echocardiography】.

Comprehensive and Detailed Explanation From Exact Extract:

Visualization of a patent ductus arteriosus (PDA) typically requires imaging planes that include the aortic arch and pulmonary artery, which are well seen from the suprasternal notch window and the basal parasternal short axis view.

The suprasternal notch window provides a longitudinal view of the aortic arch and adjacent pulmonary artery, where the PDA is located. The basal parasternal short axis at the level of the great vessels can also visualize flow through the PDA using color Doppler.

Other views like parasternal long axis and apical views are less optimal for direct PDA visualization.

This is detailed in the "Textbook of Clinical Echocardiography, 6e", Chapter on Congenital Heart Defects and PDA Imaging【20:370-375†Textbook of Clinical Echocardiography】.

Systemic hypertension leads to increased afterload, resulting in concentric left ventricular hypertrophy as an adaptive response. Chronic hypertension also causes aortic root dilation and elevated filling pressures leading to left atrial enlargement.

Restrictive cardiomyopathy primarily shows normal wall thickness with impaired filling. Hypertrophic cardiomyopathy involves asymmetric septal hypertrophy. Pulmonary hypertension mainly affects the right heart.

This association is outlined in the "Textbook of Clinical Echocardiography, 6e", Chapter on Hypertensive Heart Disease【20:345-350†Textbook of Clinical Echocardiography】.

The Doppler waveform shows pulmonary vein flow with several components. The arrows point to small reversed flow spikes just after the atrial contraction wave, which corresponds to the atrial reversal (AR) flow component. Atrial reversal occurs as blood briefly flows backward into the pulmonary veins during atrial contraction.

Ventricular reversal is not typically seen in pulmonary veins. Diastolic flow reversal is abnormal and usually not part of normal pulmonary vein flow. Systolic forward flow is the major forward component during ventricular systole.

This interpretation is standard in ASE guidelines on diastolic function assessment and pulmonary vein Doppler evaluation【12:ASE Diastolic Function Guidelines†p.85-90】【16:Textbook of Clinical Echocardiography, 6e†p.130-135】.

The echocardiographic image is a parasternal long axis or apical view showing the left ventricle. The arrow points to the wall segment located inferiorly, corresponding to the inferior wall of the left ventricle. The inferior wall is typically visualized in parasternal long axis and apical views as the posterior aspect of the ventricle.

Other options correspond to different walls: anterior is anterior septal wall, anterolateral and inferolateral refer to the lateral wall regions. Accurate wall identification is critical for regional wall motion analysis and coronary artery territory correlation.

This segmental wall identification is detailed in adult echocardiography and ASE chamber quantification guidelines【12:ASE Chamber Quantification Guidelines†p.90-95】【16:Textbook of Clinical Echocardiography, 6e†p.140-145】.

Takotsubo cardiomyopathy, also known as stress-induced cardiomyopathy or "broken heart syndrome," predominantly affects postmenopausal women (usually older than 50 years) and often presents with acute chest pain and ST-segment elevation on the ECG mimicking acute myocardial infarction. However, coronary angiography reveals normal or non-obstructive coronary arteries.

Echocardiographically, Takotsubo cardiomyopathy is characterized by transient left ventricular systolic dysfunction with a typical pattern of apical ballooning and basal hyperkinesis. The wall motion abnormality extends beyond a single coronary artery territory, differentiating it from ischemic cardiomyopathy.

The diagnosis is supported by the clinical presentation, typical echocardiographic findings, and exclusion of obstructive coronary artery disease. The condition is usually reversible over days to weeks.

This is extensively described in the "Textbook of Clinical Echocardiography, 6e" (Chapter 8: Coronary Artery Disease and Takotsubo Syndrome), which highlights the typical patient demographics, presentation, echocardiographic features, and prognosis .

The arrow points to the left anterior descending (LAD) coronary artery, which runs in the anterior interventricular groove toward the apex of the heart. It supplies the anterior wall of the left ventricle.

The right coronary artery runs in the right atrioventricular groove. The left main coronary artery is proximal to the LAD and circumflex arteries. The circumflex artery runs in the left atrioventricular groove posteriorly.

This identification is detailed in the "Textbook of Clinical Echocardiography, 6e", Chapter on Coronary Artery Anatomy and Echocardiographic Visualization【20:150-155†Textbook of Clinical Echocardiography】.